Heartworm & Flea Preventative Chart

Always consult with your veterinarian as to the best Heartworm and flea preventative for your pets environmental living condition. No product is the best for every situation.

*** Information for this comparison was pulled directly from the manufacturers. Price averages are from Charlotte region veterinary facilities.

Product Parasites Covered Cost for 6 Months Active Ingredient Information Safe To Give
Capstar Fleas $30 Nitenpyram Most fleas gone in 30 minutes. All fleas gone in 24 hours. Lasts 24 hours. Affects adult fleas 4 weeks and older, 2lbs or more.
Comfortis Fleas. Not labeled for ticks, however kills them for up to 16 days. 5-10lbs: $88.66
10-20lbs: $90.34
20-40lbs: $93.66
40-60lbs: $95.34
60-120lbs: $98.70
Spinosad, (same chemical used in Organic Farming due to break down rate). Most fleas gone in 30 minutes, all fleas gone in 4 hours. Lasts 30 days. Affects adult fleas 14 weeks of age or older, 5lbs or more
Heartguard Plus Heartworms, Hookworms, Roundworms 1-25lbs: $32.40
26-50lbs: $42.00
51-100lbs: $50.64
Ivermectin / Pyrante Safe for pregnant canines. Active for 30 days. 6 weeks of age and older.
Interceptor Heartworms, Hookworms, Roundworms, Whipworms 2-10lbs: $34.20
11-25lbs: $35.10
26-50lbs: $42.75
51-100lbs: $52.85
Milbemycinoxime Tested in pregnant canines. Active for 30 days. 4 weeks and older, 2lbs and up.
Sentinel Fleas, Heartworms, Roundworms, Whipworms, Hookworms 2-10lbs: $72.25
11-25lbs: $74.80
26-50lbs: $83.30
51-100lbs: $86.40
Milbemycinoxime / Lufenuron Tested in pregnant canines. Active for 30 days. 4 weeks and older, 2lbs and up.
Advantage Fleas $35-$75 Imidacloprid Kills adult fleas, flea larvae and chewing lice, (12 hours to 1 week) Lasts 30 days 7 weeks and older, 3lbs and up
Advantage Fleas, Heartworms 3-9lbs: $85.00 Imidacloprid / Molidectin Lasts 30 days 7 weeks
Frontline Plus Fleas, Ticks, Chewing Lice, Sarcoptic Mange 0-22lbs: $88.54
23-44lbs: $90.68
45-88lbs: $92.92
89-132lbs: $94.96
Fipronil(s) Methoprine Adult Fleas, eggs, larvae, Ticks, (American Dog, Lone Star, and Deer). Safe for pregnant/lactating females. Labeled 30 days, lasts up to 6 weeks. 8 weeks and up
Revolution Fleas, Ticks, Heartworms, Ear Mites, Sarcoptic Mange 5-10lbs: $50.13
11-20lbs: $$51.48
20-40lbs: $53.01
40-85lbs: $54.36
85-130lbs: $71.82
Selamectin Adult Fleas, eggs, American Dog Tick. Lasts 30 days 6 weeks and up, 5lbs and up
K9 Advantix Fleas, Ticks, Mosquitos 0-10lbs: $59.00
11-20lbs: $62.00
21-55lbs: $64.00
55lbs & up: $68.00
Imidacloprid / Permethrin American Dog Ticks, Lone Star Ticks, Deer Ticks, Brown Dog Ticks, kills fleas in 12 hours. Lasts 30 days. 7 weeks and up